Have a Mac? Back up often? If the answer is yes and then no, then Apple has got you covered. Found via Digg, this elaborate, yet simple page gets into the nitty gritty of how to properly back up your system through .Mac Backup and other methods, including manual. I am unsure if Apple OS X includes the great Linux program rsync by default, but if you are willing to code a few lines, it can prove to be an awesome command-line backup application as well.
Regardless of which method(s) you choose, you should store at least one copy of your backup outside the computer to guard against common risks such as theft or power issues, including lightning. You may also wish to store a copy of important data at a second site to guard against property destruction, such as fire and natural disasters.
Source: Apple.com